Zhanghua Chen

Assistant Professor, Preventive Medicine, University of Southern California

Publications

2020

Chen Z, Yang T, Walker DI, Thomas DC, Qiu C, Chatzi L, Alderete TL, Kim JS, Conti DV, Breton CV, Liang D, Hauser ER, Jones DP, Gilliland FD. Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults. Environment international 2020;145:106091, Lead the study design, supervise the statistical analysis and write the manuscript.
https://pubmed.ncbi.nlm.nih.gov/32892005/

Mak ACY, Sajuthi S, Joo J, Xiao S, Sleiman PM, White MJ, Lee EY, Saef B, Hu D, Gui H, Keys KL, Lurmann F, Jain D, Abecasis G, Kang HM, Nickerson DA, Germer S, Zody MC, Winterkorn L, Reeves C, Huntsman S, Eng C, Salazar S, Oh SS, Gilliland FD, Chen Z, Kumar R, Martinez FD, Wu AC, Ziv E, Hakonarson H, Himes BE, Williams LK, Seibold MA, Burchard EG. Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and
Gene-By-Air-Pollution Interaction
. Genetics. 2020. doi: 10.1534/genetics.120.303231. PMID: 32327564, contribute to the study design, supervise the statistical analysis and review and edit the manuscript.
https://pubmed.ncbi.nlm.nih.gov/32327564/

Fouladi F, Bailey MJ, Patterson WB, Sioda M, Blakley IC, Fodor AA, Jones RB, Chen Z, Kim JS, Lurmann F, Martino C, Knight R, Gilliland FD, Alderete TL. Air Pollution Exposure Is Associated With the Gut Microbiome as Revealed by Shotgun Metagenomic Sequencing. Environment International. 138:105604, 2020. PMID: 32135388, PMC7181344, contribute to the study design and results interpretation and discussion.
https://pubmed.ncbi.nlm.nih.gov/32135388/

2019

Kim J, Chen Z, Alderete TL, Toledo-Corral C, Lurmann F, Berhane K, Gilliland FD. Associations of Air Pollution, Obesity and Cardiometabolic Health in Young Adults: The Meta-AIR Study. Environment International. 2019 133(Pt A): 105180.
https://pubmed.ncbi.nlm.nih.gov/31622905/

Zhang Y, Chen Z, Berhane K, Urman R, Chatzi VL, Breton C, and Gilliland FD. The Dynamic Relationship between Asthma and Obesity in School Children. American Journal of Epidemiology. 2019. kwz257, https://doi.org/10.1093/aje/kwz257.
https://pubmed.ncbi.nlm.nih.gov/31712801/

Chen Z, Newgard CB, Kim JS, IIkayeva O, Alderete TL, Thomas DC, Berhane K, Breton C, Chatzi L, Bastain TM, McConnell R, Avol E, Lurmann F, Muehlbauer MJ, Hauser ER, and Gilliland FD. Near-roadway Air Pollution Exposure and Altered Fatty Acid Oxidation Among Adolescents and Young Adults – the Interplay with Obesity. Environment International, 2019 130: 104935.
https://pubmed.ncbi.nlm.nih.gov/31238265/

Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Tejedor NV, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo Y, Standl M, Leinonen JT, Holm J, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi M, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SI, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin M, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VW and Grant SFA. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals New Loci Associated with Childhood Obesity. Human Molecular Genetics, 2019 pii: ddz161.
https://pubmed.ncbi.nlm.nih.gov/31504550/

Garcia E, Berhane KT, Islam T, McConnell RS, Urman R, Chen Z, Gilliland FD. Effects of reductions in regional air pollution on asthma incidence in the Southern California Children: a quasi-experimental multi-level cohort study. JAMA. 2019 321(19):1906-1915.

Alderete TL, Jin R, Walker D, Valvi D, Chen Z, Jones DP, Peng C, Gilliland F, Berhane K, Conti D, Goran MI, Chatzi L. Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis. Environment International. 2019 126: 445-453.
https://www.sciencedirect.com/science/article/pii/S0160412018326758

Middeldorp, C. M., …, Chen Z,… McCarthy M.I. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. European Journal of Epidemiology. 2019.
https://link.springer.com/article/10.1007/s10654-019-00502-9

Chen Z, Herting MM, Chatzi L, Belcher BR, Alderete TL, McConnell RS, and Gilliland FD. Regional and Traffic-related Air Pollutants Are Associated with Higher Consumption of High Fat and Fast Food among Adolescents. The American Journal of Clinical Nutrition. 2019 109(1): 99-108.
https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqy232/5266897
https://news.usc.edu/153762/usc-study-on-air-pollution-and-obesity-in-teens/

2018

Alderete TL*, Chen Z*, Toledo-Corral CM*, Contreras ZA, Kim JS, Habre R, Chatzi L, Bastain T, Breton CV, and Gilliland FD. Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes. Current Epidemiology Reports. 2018; 5(2):79-91.
*Shared first-authorship
https://link.springer.com/article/10.1007/s40471-018-0140-5

Contreras ZA, Chen Z, Roumeliotaki T, Annesi-Maesano I, Baïz N, Berg AV, Bergström A, Crozier S, Duijts L, Ekström S, Eller E, Fantini MP, Kjaer HF, Forastiere F, Gerhard B, Gori D, Ginkel MWH, Heinrich J, Iñiguez C, Inskip H, Keil T, Kogevinas M, Lau S, Lehmann I, Maier D, Meel ERV, Mommers M, Murcia M, Porta D, Smit HAS, Standl M, Stratakis N, Sunyer J, Thijs C, Torrent M, Vrijkotte TGM, Wijga AH, Berhane K, Gilliland FD, and Chatzi L. Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European birth cohorts. European Respiratory Journal, 2018; 52(3).
https://www.ncbi.nlm.nih.gov/pubmed/30209194

Croteau-Chonka DC, Chen Z, Barnes KC, Barraza-Villarreal A, Celedón JC, Gauderman WJ, Gilliland FD, Krishnan JA, Lemanske RF, Liu AH, London SJ, Martinez FD, Millstein J, Naureckas ET, Nicolae DL, Ober C, Weiss ST, White SR, and Raby BA, on behalf of the Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium. Gene co-expression networks in whole blood implicate multiple interrelated molecular pathways in obese asthma. Obesity, 2018. doi: 10.1002/oby.22341.

Kim S, Alderete TL, Chen Z, Lurmann F, Habre R, Berhane K, and Gilliland FD. Association of Early Life Traffic Related Air Pollution and Attained Body Mass Index and Body Mass Index Growth in Childhood. Environmental Health, 2018; 17(1):64.
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22341

Waage J, Standl M, Curtin JA, Jessen L, Thorsen J, The 23andMe Research Team, AAGC collaborators, Abdellaoui A, Ahluwalia TS, Alves A, Amaral AFS, Antó JM, Arnold A, Flores C, Baurecht H, Beijsterveldt TC, Bleecker ER, Bonàs-Guarch S, Boomsma D, Brix S, Bunyavanich S, Burchard E, Chen Z, Curjuric I, Custovic A, Dekker MD, Dharmage SC, Dmitrieva J, Duijts L, Ege M, Barreto-Luis A, Gauderman WJ, Georges M, Gieger C, Gilliland FD, Granell R,
Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Hinds DA, Holt P, Imboden M, Jaddoe V, Jarvelin M, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee Y, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr E, Palviainen T, Paternoster L, Pennell C, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Schoettler N, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Tian C, Torrent M, Torrents D, Tung JY, Wang C, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Ferreira MA, Bisgaard H, Strachan D, and Bønnelykke1 K. Genome-wide association and HLA fine mapping studies identify risk loci and genetic pathways of allergic rhinitis. Nature Genetics, 2018; 50(8):1072-1080.
https://www.nature.com/articles/s41588-018-0157-1

Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, and Gilliland FD , Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research, 2018 161:472-478.
https://www.sciencedirect.com/science/article/pii/S0013935117317164?via%3Dihub

2017

Chen Z, Salam MT, Alderete TL, Habre R, Bastain TM, Berhane K, and Gilliland FD. Effects of Childhood Asthma on the Development of Obesity among School-aged Children. American Journal of Respiratory and Critical Care Medicine, 2017 195(9):1181-1188.
http://www.atsjournals.org/doi/abs/10.1164/rccm.201608-1691OC
http://news.usc.edu/115079/children-with-asthma-are-more-likely-to-become-obese-usc-study-finds/
https://www.eurekalert.org/pub_releases/2017-01/ats-cwa011717.php

Herting MM, Gautam P, Chen Z, Mezher A, and Vetter NC. Test-retest Reliability of Longitudinal Task-based fMRI—Implications for Developmental Studies. Developmental Cognitive Neuroscience. 2017 pii: S1878-9293(16)30029-9.
http://www.sciencedirect.com/science/article/pii/S1878929316300299

Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, Weigensberg MJ, Goran MI, and Gilliland FD. Longitudinal Associations between Ambient Air Pollution with Insulin Sensitivity, β-cell Function, and Adiposity in Los Angeles Latino Children. Diabetes, 2017 66(7):1789-1796.
http://diabetes.diabetesjournals.org/content/early/2017/01/27/db16-1416

2016

Chen Z, Salam MT, Toledo-Corral CM, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Wilson JP, Trigo E, and Gilliland FD. Ambient Air and Traffic Related Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans. Diabetes Care, 2016 39(4): 547-54.
http://care.diabetesjournals.org/content/39/4/547?abspop=1&patientinform-links=yes&legid=diacare%3B39%2F4%2F547
http://www.healio.com/endocrinology/diabetes/news/online/%7B0e71eb59-b785-4b81-ac7a-b7dc401c48cb%7D/air-pollutions-effects-comparable-to-obesity-in-increasing-type-2-diabetes-risk
http://www.reuters.com/article/us-health-pollution-diabetes-risks-idUSKCN0WI2ZL

Baydur A, Tran A, Pallickal L, Fong M, Grazette L, Chowdhury S, and Chen Z. Breathing Intolerance Index (BIT) and its Relation to Exercise Data: Noninvasive Assessment of Inspiratory Muscle Endurance during Rest and Exercise in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disorders. Insight Medical Publishing Journals, 2016 1(2): 11.
http://chronic-obstructive-pulmonary-disease.imedpub.com/breathing-intolerance-index-bit-and-its-relation-to-exercise-data-noninvasive-assessment-of-inspiratory-muscle-endurance-during-re.php?aid=9097

Zheng Y, Chen Z, and Lu Y. Influence Factors of Estimation Errors for Total Corneal Astigmatism Using Keratometric Astigmatism in Patients before Cataract Surgery. Journal of Cataract & Refractive Surgery, 2016 42(1): 84-94.
http://www.sciencedirect.com/science/article/pii/S0886335015011943

2015

Chen Z, Salam MT, Karim R, Toledo-Corral CM, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Taher M, Wilson JP, Trigo E, and Gilliland FD. Living near a Freeway is Associated with Lower Bone Mineral Density among Mexican Americans. Osteoporosis International, 2015 26(6): 1713-1721.
http://link.springer.com/article/10.1007%2Fs00198-015-3051-z

Chen Z, Salam MT, Eckel SP, Breton, CV, and Gilliland FD. Chronic Effects of Air Pollution on Respiratory Health in Southern California Children: Findings from the Southern California Children’s Health Study. Journal of Thoracic Disease, 2015 7(1): 46-58.
http://www.jthoracdis.com/article/view/3694

2014

Chen Z, Stram DO, Watanabe RM, Buchanan TA, Trigo E, and Xiang AH. High Caloric Intake is Associated with Worsening Insulin Resistance and Beta-cell Function in Hispanic Women after Gestational Diabetes Mellitus. Diabetes Care, 2014 37(12): 3294–3300.
http://care.diabetesjournals.org/content/early/2014/10/16/dc14-1433

Chen Z, Pereira MA, Seielstad M, Koh WP, Teo YY, Tai ES, Liu JJ, Heng KK, Yuan JM, Gross MD, and Stram DO. Joint Effects of Known Type 2 Diabetes Susceptibility Loci in a Genome-wide Association Study of Singaporean Chinese: The Singapore Chinese Health Study. PLOS ONE, 2014 9(2): e87762.
http://www.plosone.org/article/citationList.action?articleURI=info%3Adoi%2F10.1371%2Fjournal.pone.0087762

2013

Chen Z, Black MH, Watanabe RM, Trigo E, Takayanagi M, Buchanan TA, and Xiang AH. Self- reported Physical Activity is Associated with β-cell Function in Mexican American Adults. Diabetes Care, 2013 36(3): 638-644.
http://care.diabetesjournals.org/content/36/3/638.long
http://www.dailyrxnews.com/diabetes-risk-factors-reduced-mexican-americans-higher-levels-physical-activity

Baydur A and Chen Z. Breathing Intolerance Index in COPD and Obesity: A Comparative Observational Study. Open Journal of Respiratory Diseases, 2013 3(3): 119-127.
http://www.scirp.org/journal/PaperInformation.aspx?paperID=35404#.UxTRG-NhyYg

2012

Baydur A, Vigen C, and Chen Z. Expiratory Flow Limitation in Obstructive Sleep Apnea from COPD: A Quantitative Method to Detect Pattern Differences Using the Negative Expiratory Pressure Technique. The Open Respiratory Medicine Journal, 2012(6): 115-124.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496931

Kim J, Chen Z, Alderete TL, Toledo-Corral C, Lurmann F, Berhane K, Gilliland FD. Associations of Air Pollution, Obesity and Cardiometabolic Health in Young Adults: The Meta-AIR Study. Environment International. 2019 133(Pt A): 105180.
https://pubmed.ncbi.nlm.nih.gov/31622905/

Kim J, Chen Z, Alderete TL, Toledo-Corral C, Lurmann F, Berhane K, Gilliland FD. Associations of Air Pollution, Obesity and Cardiometabolic Health in Young Adults: The Meta-AIR Study. Environment International. 2019 133(Pt A): 105180.
https://pubmed.ncbi.nlm.nih.gov/31622905/